Here, we introduced the concept of strand exchange amplification (SEA) mediated by denaturation bubbles. Similar to traditional PCR, it only employed a DNA polymerase and a pair of common primers to realize a three-step cycle process, but the entire SEA reaction was performed at a single temperature.
C. Shi, F. Shang, M. Zhou, P. Zhang, Y. Wang and C. Ma, Chem. Commun., 2016, 52, 11551 DOI: 10.1039/C6CC05906F
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