Issue 45, 2023

Ph3P/ICH2CH2I-promoted reductive deoxygenation of alcohols

Abstract

Owing to the ubiquity of the hydroxyl group, reductive deoxygenation of alcohols has become an active research area. The classic Barton–McCombie reaction suffers from a tedious two-step procedure. New efficient methods have been developed, but they have some limitations, such as a narrow substrate scope and the use of moisture-sensitive Lewis acids. In this work, we describe the Ph3P/ICH2CH2I-promoted reductive deoxygenation of alcohols with NaBH4. The process is applicable to benzyl, allyl and propargyl alcohols, and also to primary and secondary alcohols, demonstrating a wide substrate scope and a good level of functional group tolerance. This protocol features convenient operation and low cost of all reagents.

Graphical abstract: Ph3P/ICH2CH2I-promoted reductive deoxygenation of alcohols

Supplementary files

Article information

Article type
Communication
Submitted
18 Oct 2023
Accepted
02 Nov 2023
First published
02 Nov 2023

Org. Biomol. Chem., 2023,21, 8989-8992

Ph3P/ICH2CH2I-promoted reductive deoxygenation of alcohols

W. Tang, X. Zheng, X. Yao, J. Lin, Q. Zheng and J. Xiao, Org. Biomol. Chem., 2023, 21, 8989 DOI: 10.1039/D3OB01698F

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