Issue 16, 2022

Ruthenium(ii)-catalyzed synthesis of CF3-isoquinolinones via C–H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides

Abstract

A ruthenium(II)-catalyzed C–H activation/annulation reaction of benzoic acids and CF3-imidoyl sulfoxonium ylides enabled by weak O-coordination has been achieved. A series of 3-trifluoromethylisoquinolinones were synthesized in 37–75% yields under redox-neutral reaction conditions.

Graphical abstract: Ruthenium(ii)-catalyzed synthesis of CF3-isoquinolinones via C–H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides

Supplementary files

Article information

Article type
Research Article
Submitted
23 May 2022
Accepted
28 Jun 2022
First published
29 Jun 2022

Org. Chem. Front., 2022,9, 4388-4393

Ruthenium(II)-catalyzed synthesis of CF3-isoquinolinones via C–H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides

S. Wen, Y. Zhang, Q. Tian, Y. Chen and G. Cheng, Org. Chem. Front., 2022, 9, 4388 DOI: 10.1039/D2QO00839D

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