Ruthenium(II)-catalyzed synthesis of CF3-isoquinolinones via C–H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides

Si Wen; Yuqing Zhang; Qingyu Tian; Yanhui Chen; Guolin Cheng

doi:10.1039/D2QO00839D

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Ruthenium(ii)-catalyzed synthesis of CF₃-isoquinolinones via C–H activation/annulation of benzoic acids and CF₃-imidoyl sulfoxonium ylides†

Si Wen,^a Yuqing Zhang,^a Qingyu Tian,^a Yanhui Chen^a and Guolin Cheng

*^a

Author affiliations

* Corresponding authors

^a Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing, College of Materials Science and Engineering, the Instrumental Analysis Center, Huaqiao University, Xiamen 361021, China
E-mail: glcheng@hqu.edu.cn

Abstract

A ruthenium(II)-catalyzed C–H activation/annulation reaction of benzoic acids and CF₃-imidoyl sulfoxonium ylides enabled by weak O-coordination has been achieved. A series of 3-trifluoromethylisoquinolinones were synthesized in 37–75% yields under redox-neutral reaction conditions.

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Article information

DOI: https://doi.org/10.1039/D2QO00839D
Article type: Research Article
Submitted: 23 May 2022
Accepted: 28 Jun 2022
First published: 29 Jun 2022

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Org. Chem. Front., 2022,9, 4388-4393

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Ruthenium(II)-catalyzed synthesis of CF₃-isoquinolinones via C–H activation/annulation of benzoic acids and CF₃-imidoyl sulfoxonium ylides

S. Wen, Y. Zhang, Q. Tian, Y. Chen and G. Cheng, Org. Chem. Front., 2022, 9, 4388 DOI: 10.1039/D2QO00839D

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