Radical-triggered annulation-haloazidation of alkynyl-bicyclo[1.1.0]butanes: an efficient route for the construction of spiro-cyclobutyl quinolinones

Abstract

A novel type of alkynyl-containing bicyclo[1.1.0]butanes (BCBs) was prepared and then applied to radical-triggered annulation-haloazidation via a three-component reaction to yield halo-azide substituted spiro-cyclobutyl quinolinones with generally excellent yields.