From the journal:

Chemical Communications

A mitochondria-targeted sequence-activated fluorescent probe responsive to H2O2 and viscosity for imaging and surgical navigation of hepatocellular carcinoma

Wen Zhang, ORCID logo a   Yuting Sheng,a   Min Zhang,a   Qiong Wang,a   Xin Wang, ORCID logo a   Hui Wang,a   Wei Zhang,a   Ping Li ORCID logo *ab  and  Bo Tang ORCID logo ac  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, Shandong, People's Republic of China
E-mail: Lip@sdnu.edu.cn

b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, Gansu, People's Republic of China

c Laoshan Laboratory, Qingdao 266237, Shandong, People's Republic of China

Abstract

A mitochondria-targeted fluorescent probe (HV) sequentially activated by H2O2 and viscosity was constructed. Probe HV exhibits high specificity and excellent biocompatibility. Due to the upregulation of mitochondrial H2O2 and viscosity in cancer cells, HV is capable of illuminating hepatocellular carcinoma. HV surpasses the limitations of single-marker detection of liver cancer and enables powerful imaging-guided hepatic cancer resections, improving the precision of liver diagnosis and treatment.

Graphical abstract: A mitochondria-targeted sequence-activated fluorescent probe responsive to H2O2 and viscosity for imaging and surgical navigation of hepatocellular carcinoma

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Article information

DOI
https://doi.org/10.1039/D5CC03664J
Article type
Communication
Submitted
30 Jun 2025
Accepted
04 Aug 2025
First published
07 Aug 2025

Chem. Commun., 2025, Advance Article

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A mitochondria-targeted sequence-activated fluorescent probe responsive to H2O2 and viscosity for imaging and surgical navigation of hepatocellular carcinoma

W. Zhang, Y. Sheng, M. Zhang, Q. Wang, X. Wang, H. Wang, W. Zhang, P. Li and B. Tang, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03664J

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