From the journal:

Chemical Communications

A dual-mode viscosity-activatable probe for the immediate evaluation of photodynamic/photothermal therapy efficacy

Ao-Xiang Fu,†a   Li Li,†a   Qin-Ting Liao,a   Chu-Yu-Hui Peng,c   Ning Yang,a   Guo-Jiang Mao, ORCID logo b   Juan Ouyang, ORCID logo a   Liufang Hu,a   Fen Xu*a  and  Chun-Yan Li ORCID logo *a  

* Corresponding authors

a Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Hunan Provincial University Key Laboratory for Environmental and Ecological Health, College of Chemistry, Xiangtan University, Xiangtan, P. R. China
E-mail: xufen@xtu.edu.cn, lichunyan@xtu.edu.cn

b Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, P. R. China

c College of Chemical Engineering, Xiangtan University, Xiangtan 411105, P. R. China

Abstract

A dual-mode probe, named BC-V, is constructed for viscosity imaging. In high-viscosity solution, the fluorescence and photoacoustic signals are triggered. Under laser irradiation, the photodynamic and photothermal properties are activated. Furthermore, during phototherapy in tumor-bearing mice, therapy efficacy can be immediately evaluated using dual-mode imaging.

Graphical abstract: A dual-mode viscosity-activatable probe for the immediate evaluation of photodynamic/photothermal therapy efficacy

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Article information

DOI
https://doi.org/10.1039/D5CC06006K
Article type
Communication
Submitted
22 Oct 2025
Accepted
13 Nov 2025
First published
14 Nov 2025

Chem. Commun., 2025, Advance Article

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A dual-mode viscosity-activatable probe for the immediate evaluation of photodynamic/photothermal therapy efficacy

A. Fu, L. Li, Q. Liao, C. Peng, N. Yang, G. Mao, J. Ouyang, L. Hu, F. Xu and C. Li, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC06006K

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