Ammonium salts as an inexpensive and convenient nitrogen source in the Cu-catalyzed amination of aryl halides at room temperature

Abstract

Convenient and inexpensive ammonium salts such as NH₄Cl and aqueous NH₃ solution are found to be readily utilized in the Cu-catalyzed room temperature N-arylation of aryl halides, providing N-unprotected aniline derivatives in high yields.