Issue 11, 2016
From the journal:

Chemical Communications

A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells†

Nuli Xie,a   Jin Huang,*a   Xiaohai Yang,a   Yanjing Yang,a   Ke Quan,a   He Wang,a   Le Ying,a   Min Oua  and  Kemin Wang*a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China
E-mail: jinhuang@hnu.edu.cn, kmwang@hnu.edu.cn

Abstract

Due to its low cytotoxicity, high resistance to enzymatic degradation, and cellular permeability, a DNA tetrahedron-based molecular beacon (DTMB) is designed for tumor-related TK1 mRNA detection in living cells, where the target sequence can induce the tetrahedron from contraction to extension, resulting in fluorescence restoration.

Graphical abstract: A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells

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Article information

DOI
https://doi.org/10.1039/C5CC09980C
Article type
Communication
Submitted
04 Dec 2015
Accepted
18 Dec 2015
First published
18 Dec 2015

Chem. Commun., 2016,52, 2346-2349

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A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells

N. Xie, J. Huang, X. Yang, Y. Yang, K. Quan, H. Wang, L. Ying, M. Ou and K. Wang, Chem. Commun., 2016, 52, 2346 DOI: 10.1039/C5CC09980C

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