Issue 48, 2023
From the journal:

Chemical Communications

A two-step lighting DNA tetrahedral nanoprobe for precise imaging-guided photodynamic therapy of tumors†

Fan Wu,a   Yuancheng Li,b   Lijuan Wang,b   Can Peng,a   Youhui Zeng,a   Jinfeng Yang,*b   Huijun Zhou*b  and  Jing Zheng ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Institute of Chemical Biology and Nanomedicine (ICBN), Hunan University, Changsha, China
E-mail: zhengjing2013@hnu.edu.cn

b Department of Gastroenterology and Urology, Department of Anesthesiology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China
E-mail: yangjinfeng@hnca.org.cn, zhouhuijun@hnca.org.cn

Abstract

Herein, we innovatively propose a mucin 1 and azoreductase dual-responsive DNA tetrahedral nanoprobe for two-step lighting imaging-guided photodynamic therapy of tumors. We hope that this highly specific, responsive and well biocompatible drug delivery system can be effectively used for the performance of cancer therapy in the hypoxia-related biomedical field.

Graphical abstract: A two-step lighting DNA tetrahedral nanoprobe for precise imaging-guided photodynamic therapy of tumors

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Article information

DOI
https://doi.org/10.1039/D3CC00883E
Article type
Communication
Submitted
24 Feb 2023
Accepted
25 Apr 2023
First published
04 May 2023

Chem. Commun., 2023,59, 7403-7406

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A two-step lighting DNA tetrahedral nanoprobe for precise imaging-guided photodynamic therapy of tumors

F. Wu, Y. Li, L. Wang, C. Peng, Y. Zeng, J. Yang, H. Zhou and J. Zheng, Chem. Commun., 2023, 59, 7403 DOI: 10.1039/D3CC00883E

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