Integrating C–H activation/2-fold annulation: a modular access to heteroaryl-tethered oxazoloisoquinolinones

Abstract

A cascade C–H activation/2-fold annulation of 2-aryloxazolines with pyridotriazoles has been achieved employing Rh-catalysis to afford heteroaryl-tethered oxazoloisoquinolinones. The synergistic annulations, functional group tolerance, and late-stage skeletal editing of the bioactive scaffolds are the salient practical features.

Graphical abstract: Integrating C–H activation/2-fold annulation: a modular access to heteroaryl-tethered oxazoloisoquinolinones

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2024
Accepted
19 Dec 2024
First published
19 Dec 2024

Chem. Commun., 2025, Advance Article

Integrating C–H activation/2-fold annulation: a modular access to heteroaryl-tethered oxazoloisoquinolinones

S. Basak, T. Paul, M. V. Nanjegowda and T. Punniyamurthy, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D4CC06123C

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