Asymmetric catalytic synthesis of chiral deuterated compounds

Abstract

Deuterated compounds possess significant research value. As interest in chiral deuterated compounds intensifies, various deuteration methods are garnering increased attention. This article primarily reviews the asymmetric deuterium synthesis methods reported in recent years, focusing on the following strategies: one-step synthesis of D-generation compounds, which includes reductive deuteration, the series reaction of H/D exchange and asymmetric allylation, the [3+2] asymmetric cycloaddition of 1,3-dipoles and alkenes, asymmetric deuteration via photocatalysis, asymmetric deuteration using organic catalysis, and asymmetric deuteration of chiral amino acids and their derivatives through biocatalysis.