Parasite glycoconjugates. Part 11.1 Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating α-D-mannopyranosylphosphate transferase in the Leishmania
Abstract
A set of phosphodisaccharides, substrate analogues, which will be used to study acceptor–substrate specificity of the Leishmania biosynthetic enzymes, are synthesized using the Koenigs–Knorr and trichloroacetimidate methods for the glycosylation reactions, SN2 nucleophilic displacement of a triflic ester for epimerization, and the glycosyl hydrogenphosphonate method for phosphorylation.