Conjugate additions of heteronucleophiles to enones and alkynoates. A ‘benign by design’ functionalization of heteroaromatics
Abstract
A simple and convenient functionalization of pyrrole and thiophene nuclei has been accomplished by one-step clay-catalyzed conjugate addition reactions of these heteroaromatics with some enones and alkynoates under very mild conditions. The experimental protocol can be easily modified to accommodate one or two alkyl groups.