A simple and convenient functionalization of pyrrole and thiophene nuclei has been accomplished by one-step clay-catalyzed conjugate addition reactions of these heteroaromatics with some enones and alkynoates under very mild conditions. The experimental protocol can be easily modified to accommodate one or two alkyl groups.
Conjugate additions of heteronucleophiles to enones and alkynoates. A ‘benign by design’ functionalization of heteroaromatics
M. Avalos, R. Babiano, J. L. Bravo, P. Cintas, J. L. Jiménez, J. C. Palacios and M. A. Silva, Green Chem., 2001, 3, 26 DOI: 10.1039/B008795P
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