Cyclopropanation of styrene with diazoacetates, performed in aqueous/organic biphasic media or homogeneous alcoholic media in the combination of toluene by using chiral bis(hydroxymethyldihydrooxazolyl)pyridine–ruthenium catalyst, resulted in high enantiomeric excess up to 96–97% and trans∶cis stereoselectivity to 97∶3.
Asymmetric cyclopropanation in protic media conducted by chiral bis(hydroxymethyl-dihydrooxazolyl)pyridine–ruthenium catalysts
S. Iwasa, F. Takezawa, Y. Tuchiya and H. Nishiyama, Chem. Commun., 2001, 59 DOI: 10.1039/B008516M
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