CF3S-triazine for dehydroxylative trifluoromethylthiolation of alcohols

Abstract

Dehydroxylative trifluoromethylthiolation of alcohols has garnered significant attention yet remains a challenging transformation due to the high bond dissociation energy of the C–OH bond. In this work, we report the use of tris(trifluoromethylthio)-1,3,5-triazine as a dual-function reagent that serves both as a CF₃S source and an activator of hydroxyl groups. The reaction proceeds under mild conditions, does not require Lewis acid activators, and converts a range of primary alcohols to the corresponding products in good to excellent yields.