Visualizing ozone fluctuations employing a fluorescent probe in stimulated-epilepsy cell models

Jian Zhang; Yu Duan; Chang Liu; Mingyue Zhang; Heng Liu; Xingchen Ming; Yong Li; Xiaoyun Jiao; Xu Wang; Bo Tang

doi:10.1039/D4CC06310D

Visualizing ozone fluctuations employing a fluorescent probe in stimulated-epilepsy cell models†

Jian Zhang,‡^ad Yu Duan,‡^a Chang Liu,^a Mingyue Zhang,^a Heng Liu,

*^c Xingchen Ming,^a Yong Li,^a Xiaoyun Jiao,^a Xu Wang*^a and Bo Tang

*^ab

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* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: wangxu@sdnu.edu.cn, tangb@sdnu.edu.cn

^b Laoshan Laboratory, Qingdao 266237, P. R. China

^c Department of Radiotherapy, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, People's Republic of China
E-mail: liuheng11b@muhn.edu.cn

^d State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200438, People's Republic of China

Abstract

BID-Ozo, a mitochondrial-targeted fluorescence probe to detect endogenous ozone (O₃) was developed. A significant increase in intracellular O₃ was observed in PC12 cells stimulated with high concentrations of glutamate (Glu), which is used to model epilepsy.

Chemical Communications

Visualizing ozone fluctuations employing a fluorescent probe in stimulated-epilepsy cell models†

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Visualizing ozone fluctuations employing a fluorescent probe in stimulated-epilepsy cell models

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