Darren J. Cundy, Andrew C. Donohue and Tom D. McCarthy
J. Chem. Soc., Perkin Trans. 1, 1999, 559-568
DOI:
10.1039/A809718F,
Paper
The paper describes the synthesis of the N-Boc lactam 4 and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-Glu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA·HCl and provided synthetic methods and full characterisation for the previously `elusive' free amino acid ADDA.