The reaction of steroidal 2α-bromo-3-ketones (e.g. 2α-bromocholestan-3-one 2) with ammonia followed by hydrolysis and air-oxidation affords the easily separable mixture of the trans and cis dimeric steroid-pyrazines (3 and 4, respectively).
Z. Łotowski, A. Gryszkiewicz, J. B. Borowiecka, A. Nikitiuk and J. W. Morzycki, J. Chem. Res. (S), 1999, 662 DOI: 10.1039/A905508H
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