New synthesis of a useful C3 chiral building block by a heterogeneous method: enantioselective hydrogenation of pyruvaldehyde dimethyl acetal over cinchona modified Pt/Al2O3 catalysts
Abstract
The first satisfactory application of the heterogeneous cinchona-modified Pt catalyst system for the synthesis of a C3 chiral building, namely, the highly enantioselective (up to 96.5% ee) hydrogenation of pyruvaldehyde dimethyl acetal to lactaldehyde dimethyl acetal is described.