A general cascade and stepwise oxidation scheme for 4-aryl-substituted 1,2,3,6-tetrahydropyridines with KMnO4 is described, which includes the consecutive oxidative transformation of the carbon triad in the substrate allylamine fragment, yielding tetrahydropyridin-2-ones, 3,4-dihydroxypiperidin-2-ones and, finally, 1-formylamino-3-arylpropan-3-ones.
A. T. Soldatenkov, A. W. Temesgen, I. A. Bekro, S. A. Soldatova and B. N. Anissimov, Mendeleev Commun., 1998, 8, 137 DOI: 10.1070/MC1998v008n04ABEH000982
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