Highly diastereoselective hetero-Diels–Alder reactions of alkenyldihydrooxazoles as an approach to novel pyrimidine derivatives
Abstract
Chiral 2-alkenyldihydrooxazoles react with two equivalents of aryl and arylsulfonyl isocyanates to give chiral nonracemic dihydropyrimidone derivatives in high yield and with complete diastereocontrol.