Some physico-chemical characteristics that make D2O-based buffer solutions useful media for capillary electrophoresis
Abstract
Capillary electrophoresis (CE) carried out in deuterium oxide based buffers can give much improvement and flexibility in analysis owing to a lowering in Joule heating and an increase in the viscosity within the capillary; moreover, as most acids are weaker in deuterium oxide than in water, pKa differences can result in enhanced resolution.
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