N-substituted granatanine-3-spiro-5′-hydantoins as zwitterions. Potentiometric determination of the pK1 and pK2 values for the conjugate acids
Abstract
Remarkable pK1, and pK2 values for N-substituted granataninespirohydantoins which have the zwitterion structure (II) have been found by potentiometry. Previously proposed conformations for the conjugate acids (H2Z+) and the zwitterion forms (HZ+–) may explain these values.