Nucleophilic attack by amine nitrogen on the ionised carboxy group
Abstract
The 2-(1-aminoethyl)benzoate anion cyclises to the lactam (3) at high pH, in a reaction which involves intramolecular attack of amine nitrogen on the carboxylate anion.
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Article information
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J. Chem. Soc., Chem. Commun., 1978, 807-808
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Nucleophilic attack by amine nitrogen on the ionised carboxy group
P. Camilleri, A. Cassola, A. J. Kirby and T. G. Mujahid, J. Chem. Soc., Chem. Commun., 1978, 807 DOI: 10.1039/C39780000807
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