Total synthesis of (±)-mecambridine (1,10,11-trimethoxy-2,3-methylenedioxyberbin-12-ylmethanol)
Abstract
Hydroxymethylation of 1,10-dimethoxy-2,3-methylenedioxyberbin-11-ol (5), followed by O-methylation, gave (±)-mecambridine (2), thus confirming the suggested structure of the latter.