The ortho : para ratio in aromatic nucleophilic substitution
Abstract
Summary p-Nitrofluorobenzene reacts slightly faster than o-nitrofluorobenzene with methoxide ions in methanol, but under the same conditions the 2-fluorine atom in 2,4-difluoronitrobenzene is replaced faster than the 4-fluorine atom; an explanation is given to reconcile these observations.