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Issue 17, 2020
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Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes

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Abstract

Nickel-catalyzed three-component alkene difunctionalization has rapidly emerged as a powerful tool for forging two C–C bonds in a single reaction. Building upon the powerful modes of bond construction in traditional two-component cross-coupling, various research groups have demonstrated the versatility of nickel in enabling catalytic 1,2-dicarbofunctionalization using a wide range of carbon-based electrophiles and nucleophiles and in a fully intermolecular fashion. Though this area has emerged only recently, the last few years have witnessed a proliferation of publications on this topic, underscoring the potential of this strategy to develop into a general platform that offers high regio- and stereoselectivity. This minireview highlights the recent progress in the area of intermolecular 1,2-dicarbofunctionalization of alkenes via nickel catalysis and discusses lingering challenges within this reactivity paradigm.

Graphical abstract: Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes

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Article information


Submitted
27 Nov 2019
Accepted
04 Mar 2020
First published
06 Mar 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 4287-4296
Article type
Minireview

Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes

J. Derosa, O. Apolinar, T. Kang, V. T. Tran and K. M. Engle, Chem. Sci., 2020, 11, 4287
DOI: 10.1039/C9SC06006E

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