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Issue 23, 2019
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Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

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Abstract

A set of metal–organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells––including those resistant to cisplatin––and in zebrafish embryos. In cultured cells, M-TKs generated reactive oxygen species that triggered apoptosis via the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal–organic knots as a new field of chemical space for pharmaceutical design and development.

Graphical abstract: Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

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Supplementary files

Article information


Submitted
12 Mar 2019
Accepted
26 Apr 2019
First published
22 May 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 5884-5892
Article type
Edge Article

Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

F. Benyettou, T. Prakasam, A. Ramdas Nair, I. Witzel, M. Alhashimi, T. Skorjanc, J. Olsen, K. C. Sadler and A. Trabolsi, Chem. Sci., 2019, 10, 5884 DOI: 10.1039/C9SC01218D

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