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Issue 54, 2020
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Regio- and stereoselective intermolecular carbolithiation reactions

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Abstract

The inter-molecular carbolithiation of unfunctionalized and functionalized alkenes, followed by electrophile trapping, provides a versatile and useful tool for the construction of complex molecular systems, allowing the simultaneous creation of up to two novel carbon–carbon or carbon–heteroatom bonds. In this review a full overview on inter-molecular carbolithiation processes is reported, with a main focus on the chemo-, regio- and stereo-control of the reaction and on the strategies for asymmetric processes.

Graphical abstract: Regio- and stereoselective intermolecular carbolithiation reactions

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Article information


Submitted
13 Jul 2020
Accepted
22 Aug 2020
First published
02 Sep 2020

This article is Open Access

RSC Adv., 2020,10, 32581-32601
Article type
Review Article

Regio- and stereoselective intermolecular carbolithiation reactions

G. Marsico, P. Scafato, S. Belviso and S. Superchi, RSC Adv., 2020, 10, 32581
DOI: 10.1039/D0RA06101H

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    [Original citation] - Published by The Royal Society of Chemistry.

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