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Issue 14, 2020
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Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

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Abstract

This study describes the use of highly versatile, lithographically defined magnetic microdiscs. Gold covered magnetic microdiscs are used in both radiosensitizing cancer cells, acting as intracellular emitters of secondary electrons during radiotherapy, and as well as inducing mechanical damage by exerting a mechanical torque when exposed to a rotating magnetic field. This study reveals that lithographically defined microdiscs with a uniform size of 2 microns in diameter highly increase the DNA damage and reduce the glioblastoma colony formation potential compared to conventional radiation therapy. Furthermore, the addition of mechanical disruption mediated by the magnetic component of the discs increased the efficiency of brain cancer cell killing.

Graphical abstract: Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

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Supplementary files

Article information


Submitted
07 Jan 2020
Accepted
06 Feb 2020
First published
25 Feb 2020

This article is Open Access

RSC Adv., 2020,10, 8161-8171
Article type
Paper

Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

S. Leulmi Pichot, S. Bentouati, S. S. Ahmad, M. Sotiropoulos, R. Jena and R. Cowburn, RSC Adv., 2020, 10, 8161
DOI: 10.1039/D0RA00164C

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