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Issue 4, 2020
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Asymmetric catalysis in direct nitromethane-free Henry reactions

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Abstract

A great number of reports have described asymmetric catalytic Henry reactions using nitromethanes as pronucleophiles, but far more challenging is diastereoselective catalytic Henry reactions using substituted higher nitroalkanes instead of nitromethane to generate chiral β-nitro alcohol scaffolds with four adjacent stereogenic centers in a one-pot operation. This review summarizes the current state and applications of such reactions involving complex nitroalkane coupling with various carbonyl compounds for resolving double chiral centers with high enantio- and diastereoselectivities.

Graphical abstract: Asymmetric catalysis in direct nitromethane-free Henry reactions

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Article information


Submitted
07 Dec 2019
Accepted
06 Jan 2020
First published
13 Jan 2020

This article is Open Access

RSC Adv., 2020,10, 2313-2326
Article type
Review Article

Asymmetric catalysis in direct nitromethane-free Henry reactions

L. Dong and F. Chen, RSC Adv., 2020, 10, 2313
DOI: 10.1039/C9RA10263A

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