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Issue 1, 2020
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Antimicrobial peptides from Bombyx mori: a splendid immune defense response in silkworms

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Abstract

Bombyx mori L., a primary producer of silk, is the main tool in the sericulture industry and provides the means of livelihood to a large number of people. Silk cocoon crop losses due to bacterial infection pose a major threat to the sericulture industry. Bombyx mori L., a silkworm of the mulberry type, has a sophisticated inherent innate immune mechanism to combat such invasive pathogens. Among all the components in this defense system, antimicrobial peptides (AMPs) are notable due to their specificity towards the invading pathogens without harming the normal host cells. Bombyx mori L. so far has had AMPs identified that belong to six different families, namely cecropin, defensin, moricin, gloverin, attacin and lebocin, which are produced by the Toll and immune deficiency (IMD) pathways. Their diverse modes of action depend on microbial pathogens and are still under investigation. This review examines the recent progress in understanding the immune defense mechanism of Bombyx mori based on AMPs.

Graphical abstract: Antimicrobial peptides from Bombyx mori: a splendid immune defense response in silkworms

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Article information


Submitted
29 Aug 2019
Accepted
15 Dec 2019
First published
02 Jan 2020

This article is Open Access

RSC Adv., 2020,10, 512-523
Article type
Review Article

Antimicrobial peptides from Bombyx mori: a splendid immune defense response in silkworms

J. Nesa, A. Sadat, D. F. Buccini, A. Kati, A. K. Mandal and O. L. Franco, RSC Adv., 2020, 10, 512
DOI: 10.1039/C9RA06864C

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