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Issue 8, 2012
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Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

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Abstract

This work aims to show the viability of applying video imaging techniques to the cooling crystallization of paracetamol in an oscillatory baffled crystallizer for the determination of the metastable zone width and crystal size distribution. From these data, the effects of supersaturation and mixing on metastable zone width and mean particle size are examined. Both sets of data are in good agreement with previous studies in a stirred tank and oscillatory baffled crystallizers. Finally, utilizing the Kubota's interpretation of metastable zone width, we demonstrated that the video imaging techniques are as sensitive to nucleation events as FBRM probes.

Graphical abstract: Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

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Article information


Submitted
05 Dec 2011
Accepted
16 Jan 2012
First published
17 Feb 2012

CrystEngComm, 2012,14, 2944-2949
Article type
Paper

Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

C. J. Brown and X. Ni, CrystEngComm, 2012, 14, 2944
DOI: 10.1039/C2CE06628A

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