Jump to main content
Jump to site search

Issue 8, 2012
Previous Article Next Article

Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

Author affiliations

Abstract

This work aims to show the viability of applying video imaging techniques to the cooling crystallization of paracetamol in an oscillatory baffled crystallizer for the determination of the metastable zone width and crystal size distribution. From these data, the effects of supersaturation and mixing on metastable zone width and mean particle size are examined. Both sets of data are in good agreement with previous studies in a stirred tank and oscillatory baffled crystallizers. Finally, utilizing the Kubota's interpretation of metastable zone width, we demonstrated that the video imaging techniques are as sensitive to nucleation events as FBRM probes.

Graphical abstract: Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

Back to tab navigation

Publication details

The article was received on 05 Dec 2011, accepted on 16 Jan 2012 and first published on 17 Feb 2012


Article type: Paper
DOI: 10.1039/C2CE06628A
Citation: CrystEngComm, 2012,14, 2944-2949
  •   Request permissions

    Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

    C. J. Brown and X. Ni, CrystEngComm, 2012, 14, 2944
    DOI: 10.1039/C2CE06628A

Search articles by author

Spotlight

Advertisements