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Issue 9, 2011
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Crystal structures of mirtazapine molecular salts

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Abstract

A few molecular salts of the anti-depressant drug R/S-Mirtazapine with organic carboxylic acids, its HCl salt, and Mirtazapine hemihydrate were crystallized and characterized by X-ray diffraction, IR and Raman spectroscopy, and thermal analysis. Whereas Mirtazapine base sublimed above ambient conditions its molecular salts do not show any sublimation even at elevated temperatures. Crystal structure analysis showed that proton transfer in the hemiadipate salt occurs contrary to the ΔpKa rule. A strong ionic two-point synthon of N+–H⋯O and C–H⋯Ohydrogen bonds is a recurring motif in Mirtazapinium carboxylate crystal structures.

Graphical abstract: Crystal structures of mirtazapine molecular salts

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Article information


Submitted
20 Oct 2010
Accepted
05 Jan 2011
First published
22 Feb 2011

CrystEngComm, 2011,13, 3232-3240
Article type
Paper

Crystal structures of mirtazapine molecular salts

B. Sarma, R. Thakuria, N. K. Nath and A. Nangia, CrystEngComm, 2011, 13, 3232
DOI: 10.1039/C0CE00746C

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