Issue 88, 2015

A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

Abstract

In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a MW of 49 472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified β-cyclodextrin) 60 fold, yet cause no increase in toxicity.

Graphical abstract: A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

Supplementary files

Article information

Article type
Communication
Submitted
25 Jun 2015
Accepted
26 Aug 2015
First published
26 Aug 2015

Chem. Commun., 2015,51, 15956-15959

A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

S. Maity, P. Choudhary, M. Manjunath, A. Kulkarni and N. Murthy, Chem. Commun., 2015, 51, 15956 DOI: 10.1039/C5CC05242D

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