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Issue 55, 2015
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Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations

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Abstract

A modular approach combining inverse electron-demand Diels–Alder coupling (DARinv) and oxime ligation expands the toolbox of bioorthogonal peptide chemistry. Applicability of versatile site-specific bifunctional building blocks is demonstrated by generation of defined conjugates comprising linear, cystine-bridged and multi-disulfide functional peptides as well as their conjugation with hybrid silsesquioxane nanoparticles.

Graphical abstract: Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations

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Publication details

The article was received on 24 Apr 2015, accepted on 10 Jun 2015 and first published on 10 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC03434E
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Citation: Chem. Commun., 2015,51, 11130-11133
  • Open access: Creative Commons BY-NC license
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    Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations

    S. Hörner, C. Uth, O. Avrutina, H. Frauendorf, M. Wiessler and H. Kolmar, Chem. Commun., 2015, 51, 11130
    DOI: 10.1039/C5CC03434E

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