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Issue 10, 2013
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Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

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Abstract

Single crystal X-ray diffraction shows that Zr(IV) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with 89Zr.

Graphical abstract: Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

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Submitted
16 Oct 2012
Accepted
11 Dec 2012
First published
12 Dec 2012

Chem. Commun., 2013,49, 1002-1004
Article type
Communication

Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

F. Guérard, Y. Lee, R. Tripier, L. P. Szajek, J. R. Deschamps and M. W. Brechbiel, Chem. Commun., 2013, 49, 1002
DOI: 10.1039/C2CC37549D

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