Issue 24, 2018
From the journal:

Analytical Methods

Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device†

Hua Li, ORCID logo a   Daewoo Han, ORCID logo a   Giovanni M. Pauletti,b   Michael A. Hegenerb  and  Andrew J. Steckl ORCID logo *a  

* Corresponding authors

a Nanoelectronics Laboratory, Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, USA
E-mail: a.steckl@uc.edu

b James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, USA

Abstract

A simple method to correct the effect of hematocrit (Hct) on a paper-based lateral flow assay device that is designed to assess whole blood coagulation is reported. By quantifying the effect of Hct on red blood cell (RBC) transport, a calibration procedure is obtained that compensates for the Hct effect, while maintaining the dependence of blood coagulation on RBC transport.

Graphical abstract: Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device

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Article information

DOI
https://doi.org/10.1039/C8AY00192H
Article type
Paper
Submitted
25 Jan 2018
Accepted
15 May 2018
First published
17 May 2018

Anal. Methods, 2018,10, 2869-2874

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Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device

H. Li, D. Han, Giovanni M. Pauletti, M. A. Hegener and A. J. Steckl, Anal. Methods, 2018, 10, 2869 DOI: 10.1039/C8AY00192H

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