A carbohydrate-based graphene field-effect transistor sensing system for rapid blood type detection

Abstract

Blood typing is essential in fields such as blood transfusion, organ transplantation and forensic identification. Traditional blood typing methods are usually time-consuming, operationally complex, and reliant on large-scale laboratory equipment, limiting their application in point-of-care testing. Therefore, the development of a rapid and portable blood typing method is of great significance for clinical diagnosis and emergency medical care. In this work, we develop a novel dual-channel carbohydrate-based graphene field-effect transistor (C-GFET) sensing system to achieve rapid ABO blood typing. By functionalizing the graphene surface with aminated antigen trisaccharides, the system enables the detection of blood type markers in real serum samples and determines the blood type based on the detection results. The results demonstrate that the device can specifically distinguish different blood type samples, offering a promising new strategy for point-of-care blood typing.