Photocatalytic Multicomponent Alkene Dicarbofunctionalization via PCET/Nickel Dual Catalysis

Abstract

Herein we report a synergistic photoredox PCET/nickel dual catalytic strategy that enables three-component alkene dicarbofunctionalization (DCF) using unprotected alcohols as alkyl radical precursors. This transformation merges concerted proton-coupled electron transfer (PCET) activation of alcohols with nickel-catalyzed cross-coupling, achieving sequential Giese addition and C(sp³)–C(sp³), C(sp³)–C(sp²) bond formation under visible light and redox-neutral conditions. The method proceeds directly from secondary and tertiary alcohols, exhibits broad functional-group tolerance. Notably, employing a chiral Ni catalyst enables the first enantioselective variant of this type of PCET mediated transformation. This work establishes a general platform for deconstructive alkene difunctionalization from simple alcohol feedstocks, expanding the synthetic reach of PCET in dual catalytic radical chemistry.