MIK-I: a portable low-cost platform for automated C–C bond synthesis

Abstract

The formation of C–C bonds through automated synthesis platforms aims to accelerate the preparation of molecules, simplify operational processes, and reduce the human time involved in the preparation of molecules. Here, we report different C–C bond formation reactions using a low-cost automated synthesis platform that aims to make automated organic synthesis more affordable. The platform, MIK-I, is capable of performing reactions widely used in organic chemistry, such as Claisen–Schmidt condensations, Suzuki–Miyaura couplings, Knoevenagel condensations, and Baylis–Hillman reactions, with similar yields obtained manually. This result highlights the platform's potential to operate under a basic scheme of synthesis to generate molecules of interest in organic chemistry.