Insights into the daily functions of radix Panax notoginseng

Abstract

A total of 48 compounds, including 6 undescribed triterpenoid saponins, notoginsenosides V1–V6 (1–6), were isolated and identified from the radix of Panax notoginseng. Their structures were elucidated by combining various spectroscopic techniques, such as NMR and MS analyses. Among them, (2S)-1-O-(9Z,12Z-octadecadienoyl)-3-O-β-galactopyranosylglycerol (43) exhibited the strongest anti-inflammatory activity against cyclooxygenase-2. The compounds 7, 14, 15, 16, 28, 29, 30, 39, 43, and 45 promoted the proliferation of human oral mucosa fibroblasts (hOMFs). Additionally, the compounds 1, 8, 9, 14, 35, 43, and 45 promoted the proliferation of human dermal papilla cells (hDPCs). These results revealed the potential daily functional benefits of P. notoginseng, including ameliorating oral ulcer conditions and preventing hair loss.