Issue 4, 2026, Issue in Progress
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RSC Advances

Sequential electroporation and biomimetic mineralization on an E. coli biotemplate: green synthesis of functional porous hollow calcium phosphate capsules

Wen Jiang,†a   Fengwu Zhang,†bc   Mengyao Bian,a   Jingxuan Hana  and  Changyu Shao ORCID logo *a  

* Corresponding authors

a Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China
E-mail: shaocy@zju.edu.cn

b Cancer Institute, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China

c Institute of Translational Medicine Zhejiang University School of Medicine, Hangzhou, China

Abstract

By leveraging E. coli as a biotemplate combined with electroporation and biomimetic mineralization, we developed biosafe porous hollow calcium phosphate capsules (PHCPCs) with a well-defined structure. This approach enables the precise and tunable encapsulation of various cargoes, such as therapeutic drugs and single/multiple metal oxide nanoparticles.

Graphical abstract: Sequential electroporation and biomimetic mineralization on an E. coli biotemplate: green synthesis of functional porous hollow calcium phosphate capsules

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Article information

DOI
https://doi.org/10.1039/D5RA06501A
Article type
Paper
Submitted
30 Aug 2025
Accepted
30 Dec 2025
First published
15 Jan 2026
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2026,16, 3276-3280

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Sequential electroporation and biomimetic mineralization on an E. coli biotemplate: green synthesis of functional porous hollow calcium phosphate capsules

W. Jiang, F. Zhang, M. Bian, J. Han and C. Shao, RSC Adv., 2026, 16, 3276 DOI: 10.1039/D5RA06501A

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