Issue 5, 2026, Issue in Progress
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RSC Advances

Harnessing Frémy's salt for tyrosine-directed bioconjugations

Zachary V. Samuels, ORCID logo abc   Ava Stoddard,acd   Wei-Siang Mark Kao,ac   Mike A. Cornejo,abc   Emilia Strugala,a   Shane A. McGlone,a   Lauren Furer,a   Cindy Rodriguezade  and  Brian M. Zeglis ORCID logo *abcdef  

* Corresponding authors

a Department of Chemistry, Hunter College, City University of New York, New York, NY, USA
E-mail: bz102@hunter.cuny.edu

b PhD Program in Chemistry of the Graduate Center of the City University of New York, New York, NY, USA

c Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

d PhD Program in Biology of the Graduate Center of the City University of New York, New York, NY, USA

e PhD Program in Biochemistry of the Graduate Center of the City University of New York, New York, NY, USA

f Department of Radiology, Weill Cornell Medical College, New York, NY, USA

Abstract

The current bioconjugation toolbox overwhelmingly comprises strategies that modify lysine and cysteine residues within proteins and peptides. Herein, we have leveraged Frémy's salt (potassium nitrosodisulfonate) to create an approach to bioconjugation predicated on the oxidation of tyrosine residues and the subsequent strain-promoted oxidation-controlled quinone ligation between the resultant 1,2-quinones and trans-cyclooctene-bearing cargoes.

Graphical abstract: Harnessing Frémy's salt for tyrosine-directed bioconjugations

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Article information

DOI
https://doi.org/10.1039/D5RA06489A
Article type
Paper
Submitted
29 Aug 2025
Accepted
28 Dec 2025
First published
20 Jan 2026
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2026,16, 4299-4304

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Harnessing Frémy's salt for tyrosine-directed bioconjugations

Z. V. Samuels, A. Stoddard, W. Mark Kao, M. A. Cornejo, E. Strugala, S. A. McGlone, L. Furer, C. Rodriguez and B. M. Zeglis, RSC Adv., 2026, 16, 4299 DOI: 10.1039/D5RA06489A

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