One stone two birds, diverse glycopeptides synthesis via radical Ullmann coupling from serine.

Abstract

ABSTRACT: The synergistic integration of synthetic efficiency with structural diversity constitutes a paramount objective in modern glycopeptide chemistry, addressing a critical challenge in the development of bioactive peptide therapeutics. Herein, we present an innovative "one stone, two birds" strategy that revolutionizes glycopeptide construction through sequential transformations of unified peptide precursors. Dual functionalization in a single synthetic operation and rapid assembly of glycopeptide libraries, as well as the low toxicity glycopeptides demonstrated the potential utility of this protocol.