Metal-free, Visible-Light Driven Multicomponent Reactions of Glycine Derivatives with Styrene and Disulfide Ether

Abstract

α-Amino acids and their derivatives are prevalent structural motifs with universal applications in drug discovery. Herein, we report a metal free, visible-light driven multicomponent reactions of glycine derivatives with styrene and disulfide ether. This protocol features mild and green conditions, appreciable functional group tolerance, and broad substrate scope, thus providing a sustainable and practical strategy to access synthetically valuable chalcogenated α-amino acids derivatives and peptide derivatives. Mechanistic investigations showed that imine might be the key intermediate of this transformation.