Access to α-Carbonyl Vinyl Sulfoxonium Ylides via Tandem Rearrangement-Addition of Cyclic Ethynylethylene Carbonates

Abstract

We report here a copper-catalyzed reaction of sulfoxonium ylides with cyclic ethynylethylene carbonates, enabling efficient access to highly functionalized α-carbonyl vinyl sulfoxonium ylides. This transformation proceeds via nucleophilic addition of the ylide αcarbon to an unsaturated bond, demonstrating a broad substrate scope. Notably, it offers a practical route to densely substituted tetrasubstituted olefins while preserving the versatile ylide moiety, which can be further diversified through a range of downstream transformations.