Stereoselective synthesis of β-sulfonyl and β-phosphonyl (E)-fluoroalkenes via visible-light-induced multicomponent defluorinative coupling

Abstract

Herein, we report a photocatalytic three-component radical coupling that enables the dual functionalization of alkenes with monofluoroalkenyl and sulfonyl/phosphonyl groups. This strategy offers a streamlined access to (E)-β-fluoroalkenyl sulfones and phosphonates in good yields and with high stereoselectivity from aryl gem-difluoroalkenes, various alkenes, and sodium sulfinates or diphenylphosphine oxide under mild conditions. The method is robust, exhibiting wide functional group tolerance and broad substrate scope. Furthermore, gram-scale reactions and subsequent derivatizations proceed smoothly, underscoring the practicality and scalability of our methodology