Visible-light-mediated multicomponent tribromomethyl-/arylseleno-phosphorothiolation of alkenes

Abstract

In this study, we report two operationally simple, visible-light protocols for the three-component 1,2-difunctionalization of alkenes with S-hydrogen phosphorothioates in combination with tetrabromomethane or diarylselenides. The photoinduced tribromomethylphosphorothiolation is performed via a photoredox and copper-catalyzed radical relay strategy under visible light irradiation. The arylselenophosphorothiolation is carried out with NIS/K₂S₂O₈ under metal-free conditions. Both transformations exhibit broad substrate scope, excellent functional-group tolerance and gram-scale practicality.