Photocatalytic cascade trifluoromethylation/cyclization of unactivated terminal alkenes for accessing trifluoromethyl cyclic N–H sulfoximines

Abstract

Given the critical importance of sulfoximine compounds in medicinal chemistry, we herein develop a mild, broadly applicable photocatalytic trifluoromethylation cyclization strategy for unactivated terminal alkenes, enabling the efficient synthesis of modified cyclic N–H sulfoximines. This protocol retains the N–H functionality as a valuable site for subsequent synthetic elaboration, and features low catalyst loading as well as excellent functional group tolerance that is compatible with both N–H and N-functionalized sulfoximine derivatives, thus offering an efficient and streamlined route for constructing sulfoximine-derived drug scaffolds.